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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ZFYVE16
All Species:
14.55
Human Site:
T249
Identified Species:
40
UniProt:
Q7Z3T8
Number Species:
8
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z3T8
NP_001098721.1
1539
168849
T249
F
N
M
S
S
A
L
T
R
Q
S
S
K
M
F
Chimpanzee
Pan troglodytes
XP_001135982
1539
169040
T249
F
N
M
S
S
A
L
T
Q
Q
S
S
K
M
F
Rhesus Macaque
Macaca mulatta
XP_001110183
1540
169100
T248
F
N
M
S
S
A
L
T
Q
Q
S
S
K
M
F
Dog
Lupus familis
XP_536310
1516
166814
T248
L
N
M
P
S
A
L
T
Q
Q
S
S
K
M
F
Cat
Felis silvestris
Mouse
Mus musculus
Q80U44
1528
166652
E245
D
M
P
S
V
L
M
E
Q
S
S
E
M
S
N
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510291
1525
166161
S242
E
Q
I
A
G
L
N
S
A
L
T
Q
Q
N
S
Chicken
Gallus gallus
XP_424894
1103
120204
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396901
1227
137615
E20
D
D
F
E
F
N
E
E
R
H
K
D
L
Q
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781105
1601
173741
E264
S
G
I
Q
K
P
V
E
R
M
T
T
E
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
94.3
82.8
N.A.
73.4
N.A.
N.A.
59.5
27.3
N.A.
N.A.
N.A.
N.A.
30.1
N.A.
25.1
Protein Similarity:
100
99.3
96.3
88.7
N.A.
82
N.A.
N.A.
73.2
41.3
N.A.
N.A.
N.A.
N.A.
48.7
N.A.
43.9
P-Site Identity:
100
93.3
93.3
80
N.A.
13.3
N.A.
N.A.
0
0
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
26.6
N.A.
N.A.
33.3
0
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
0
45
0
0
12
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
23
12
0
0
0
0
0
0
0
0
0
12
0
0
12
% D
% Glu:
12
0
0
12
0
0
12
34
0
0
0
12
12
0
0
% E
% Phe:
34
0
12
0
12
0
0
0
0
0
0
0
0
0
45
% F
% Gly:
0
12
0
0
12
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% H
% Ile:
0
0
23
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
12
0
0
0
0
0
12
0
45
0
0
% K
% Leu:
12
0
0
0
0
23
45
0
0
12
0
0
12
0
0
% L
% Met:
0
12
45
0
0
0
12
0
0
12
0
0
12
45
0
% M
% Asn:
0
45
0
0
0
12
12
0
0
0
0
0
0
12
12
% N
% Pro:
0
0
12
12
0
12
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
12
0
12
0
0
0
0
45
45
0
12
12
12
12
% Q
% Arg:
0
0
0
0
0
0
0
0
34
0
0
0
0
0
0
% R
% Ser:
12
0
0
45
45
0
0
12
0
12
56
45
0
12
12
% S
% Thr:
0
0
0
0
0
0
0
45
0
0
23
12
0
0
0
% T
% Val:
0
0
0
0
12
0
12
0
0
0
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _